ea0019oc6 | Young Endocrinologist prize session | SFEBES2009
Hardy R
, Ahasan M
, Patel P
, Filer A
, Rabbitt E
, Raza K
, Stewart P
, Buckley C
, Cooper M
We have previously proposed a central role for locally generated glucocorticoids in the periarticular and systemic osteoporosis seen in rheumatoid arthritis (RA). Synovial fibroblasts (SFs) express the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme and this expression increases dramatically with inflammation. Recently, production of DKK-1 (a Wnt signalling inhibitor known to inhibit bone formation) by SFs in response to inflammation has been proposed to ex...